Engineered Jurkat Cells for Targeting Prostate-Specific Membrane Antigen on Prostate Cancer Cells by Nanobody-Based Chimeric Antigen Receptor
Background: Recently, modification of T cells with chimeric blunt wraps antigen receptor (CAR) has been an attractive approach for adoptive immunotherapy of cancers.Typically, CARs contain a single-chain variable domain fragment (scFv).Most often, scfvs are derived from a monoclonal antibody of murine origin and may be a trigger for host immune sys